Placental DAAM2 is unaltered in preeclampsia, but upregulated by treatment with proton pump inhibitors

N de Alwis; S Beard; NK Binder; N Pritchard; S Tong; TJ Kaitu'u-Lino; NJ Hannan

Journal article

Placental DAAM2 is unaltered in preeclampsia, but upregulated by treatment with proton pump inhibitors

N de Alwis, S Beard, NK Binder, N Pritchard, S Tong, TJ Kaitu'u-Lino, NJ Hannan

Pregnancy Hypertension | ELSEVIER SCI LTD | Published : 2022

DOI: 10.1016/j.preghy.2022.07.005

Abstract

Background: Dishevelled Associated Activator Of Morphogenesis 2 (DAAM2) levels are elevated in the maternal circulation and placenta in pregnancies complicated by fetal growth restriction. However, placental DAAM2 levels in cases of preeclampsia have not previously been explored. Here, we examined placental DAAM2 in pregnancies complicated by preterm preeclampsia, and whether candidate preeclampsia therapeutics altered its expression. Methods: DAAM2 mRNA and protein levels were assessed in placental tissue from cases of preterm preeclampsia and gestation-matched controls (delivering ≤ 34 weeks; qPCR and western blot respectively). Short interfering RNAs were used to silence DAAM2 in isolated..

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University of Melbourne Researchers

Natasha de Alwis Author

Natalie Binder Author

Natasha Pritchard Author

Stephen Tong Author

Related Projects (3)

TRANSLATING NEW THERAPEUTICS AND DIAGNOSTICS FOR MAJOR PREGNANCY COMPLICATIONS

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DEVELOPMENT OF NOVEL THERAPEUTICS TO PREVENT OR TREAT PREECLAMPSIA

Preeclampsia, a major pregnancy complication, affects ~3-8% of pregnancies. There is no cure. We have developed new strategies to tackle the..

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Grants

Awarded by National Jewish Health

Funding Acknowledgements

Funding for salaries was provided by the National Health and Medical Research Council Fellowships to TKL (#1159261) , ST (#1136418) and NJH (#1146128) . The funders played no role in study design or analysis.